4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride

Base Information

• Chemical Name: 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride
• CAS No.: 1421961-56-9
• Molecular Formula: C₂₃H₂₆F₄N₂O*ClH
• Molecular Weight: 458.927
• Mol file: 1421961-56-9.mol

Synonyms:

Chemical Property of 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride

There total 10 articles about 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine → 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride (1421961-56-9)

Guidance literature:

With hydrogenchloride; In 2-methyltetrahydrofuran; isopropyl alcohol; at 50 ℃; for 3h; Inert atmosphere;

DOI:10.1021/op300323k

Reference yield:

C19H26FNO4 (1429661-32-4) → 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride (1421961-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -5 - 60 °C / Inert atmosphere

3.1: potassium-tert-amylate / toluene; 2-methyltetrahydrofuran / 0.55 h / 4 °C / Inert atmosphere

3.2: 4 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 2-methyltetrahydrofuran; isopropyl alcohol / 3 h / 50 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; potassium-tert-amylate; In tetrahydrofuran; 2-methyltetrahydrofuran; isopropyl alcohol; toluene;

DOI:10.1021/op300323k

Reference yield:

2-chloro-6-methyl-4-(trifluoromethyl)pyridine (22123-14-4) → 4-(((6-cyclopropyl-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidin-1-ium chloride (1421961-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: iron(III)-acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / -5 - 0 °C / Inert atmosphere

1.2: -5 - 20 °C / Inert atmosphere

2.1: trichloroisocyanuric acid / dichloromethane; N,N-dimethyl-formamide / 24 h / Inert atmosphere; Reflux

3.1: potassium-tert-amylate / toluene; 2-methyltetrahydrofuran / 0.55 h / 4 °C / Inert atmosphere

3.2: 4 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 2-methyltetrahydrofuran; isopropyl alcohol / 3 h / 50 °C / Inert atmosphere

With hydrogenchloride; iron(III)-acetylacetonate; trichloroisocyanuric acid; potassium-tert-amylate; In tetrahydrofuran; 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1021/op300323k

upstream raw materials:

tert-butyl 4-(4-fluorophenyl)-4-(hydroxymethyl)piperidine-1-carboxylate

(4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methanol

2-(chloromethyl)-6-cyclopropyl-4-(trifluoromethyl)pyridine

2-chloro-6-methyl-4-(trifluoromethyl)pyridine

Refernces