C₁₉H₂₀BrF₂N₅O

Base Information

• Chemical Name: C₁₉H₂₀BrF₂N₅O
• CAS No.: 1094568-37-2
• Molecular Formula: C₁₉H₂₀BrF₂N₅O
• Molecular Weight: 452.302
• Mol file: 1094568-37-2.mol

Synonyms:

Chemical Property of C₁₉H₂₀BrF₂N₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₀BrF₂N₅O

There total 8 articles about C₁₉H₂₀BrF₂N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H21F2N5O (1094568-32-7) → C19H20BrF2N5O (1094568-37-2)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2011.10.037

Reference yield:

C12H7ClF2N4O → C19H20BrF2N5O (1094568-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: triethylamine / 1-methyl-pyrrolidin-2-one / 24 h / 150 °C

3: thionyl chloride / dichloromethane / 1 h / 20 °C

4: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; potassium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.10.037

Reference yield:

C14H11ClF2N4O (1094568-19-0) → C19H20BrF2N5O (1094568-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 1-methyl-pyrrolidin-2-one / 24 h / 150 °C

2: thionyl chloride / dichloromethane / 1 h / 20 °C

3: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;

DOI:10.1016/j.bmcl.2011.10.037

upstream raw materials:

C₁₄H₁₁ClF₂N₄O

C₁₉H₂₃F₂N₅O₂

C₁₉H₂₁F₂N₅O

2,5-difluorobenzyl chloride

Downstream raw materials:

C₃₁H₂₉F₂N₅O

Refernces

• 1、 -. "DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b]PURIN-4(5H)-ONE AND METHODS OF USE THEREOF". Page/Page column 51. . Retrieved 2011/07/09.