Technology Process of (3aS,8aR)-2,3,5,6,7,8-hexahydro-3a,8a-methano-1H,4H-azulen-1-one (S,S)-hydrobenzoin ketal
There total 4 articles about (3aS,8aR)-2,3,5,6,7,8-hexahydro-3a,8a-methano-1H,4H-azulen-1-one (S,S)-hydrobenzoin ketal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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117583-56-9,117677-02-8
(3aS,8aR)-2,3,5,6,7,8-hexahydro-3a,8a-methano-1H,4H-azulen-1-one (S,S)-hydrobenzoin ketal
- Guidance literature:
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Multi-step reaction with 2 steps
1: 48 percent / pyridinium p-toluenesulfonate / benzene / Heating
2: 1.) Zn/Cu, iodine / 1.) diethyl ether, reflux, 30 min
With
iodine; pyridinium p-toluenesulfonate; copper; zinc;
In
benzene;
DOI:10.1021/jo00262a054
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117583-56-9,117677-02-8
(3aS,8aR)-2,3,5,6,7,8-hexahydro-3a,8a-methano-1H,4H-azulen-1-one (S,S)-hydrobenzoin ketal
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 48 percent / pyridinium p-toluenesulfonate / benzene / Heating
2: 1.) Zn/Cu, iodine / 1.) diethyl ether, reflux, 30 min
With
iodine; pyridinium p-toluenesulfonate; copper; zinc;
In
benzene;
DOI:10.1021/jo00262a054
-
-
117583-56-9,117677-02-8
(3aS,8aR)-2,3,5,6,7,8-hexahydro-3a,8a-methano-1H,4H-azulen-1-one (S,S)-hydrobenzoin ketal
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Zn/Cu, iodine / 1.) diethyl ether, reflux, 30 min
2: 90 percent / aq. HCl / methanol / 1.5 h / Ambient temperature
3: 48 percent / pyridinium p-toluenesulfonate / benzene / Heating
4: 1.) Zn/Cu, iodine / 1.) diethyl ether, reflux, 30 min
With
hydrogenchloride; iodine; pyridinium p-toluenesulfonate; copper; zinc;
In
methanol; benzene;
DOI:10.1021/jo00262a054
