Technology Process of [(E)-2-(2-Methyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
There total 4 articles about [(E)-2-(2-Methyl-1H-indol-3-yl)-ethylimino]-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80.4 percent / CF3COOH / CH2Cl2 / 1) 0 deg C, 2.5 h, 2) rt, 20 h
2: 94.5 percent / H2 / tris(triphenylphosphine)rhodium(I) chloride / benzene / 20 h / 50 °C / 7500.6 Torr
3: H2 / Pd/C / methanol / 0.5 h / Ambient temperature
4: molecular sieves / benzene / 90 h / Ambient temperature
With
molecular sieve; hydrogen; trifluoroacetic acid;
palladium on activated charcoal; Wilkinson's catalyst;
In
methanol; dichloromethane; benzene;
DOI:10.1002/hlca.19900730224
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 94.5 percent / H2 / tris(triphenylphosphine)rhodium(I) chloride / benzene / 20 h / 50 °C / 7500.6 Torr
2: H2 / Pd/C / methanol / 0.5 h / Ambient temperature
3: molecular sieves / benzene / 90 h / Ambient temperature
With
molecular sieve; hydrogen;
palladium on activated charcoal; Wilkinson's catalyst;
In
methanol; benzene;
DOI:10.1002/hlca.19900730224
- Guidance literature:
-
Multi-step reaction with 2 steps
1: H2 / Pd/C / methanol / 0.5 h / Ambient temperature
2: molecular sieves / benzene / 90 h / Ambient temperature
With
molecular sieve; hydrogen;
palladium on activated charcoal;
In
methanol; benzene;
DOI:10.1002/hlca.19900730224
