tert-butyl cyclopentanecarboxylate

Base Information

• Chemical Name: tert-butyl cyclopentanecarboxylate
• CAS No.: 87661-18-5
• Molecular Formula: C₁₀H₁₈O₂
• Molecular Weight: 170.252
• Mol file: 87661-18-5.mol

Synonyms:

Chemical Property of tert-butyl cyclopentanecarboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

TERT-BUTYL CYCLOPENTANECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl cyclopentanecarboxylate

There total 9 articles about tert-butyl cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl ether (60-29-7,927820-24-4) + sulfuric acid (7664-93-9) + cyclopentanecarboxylic acid (3400-45-1) → 1,1-dimethylethyl cyclopentanecarboxylate (87661-18-5)

Guidance literature:

With sodium hydrogencarbonate; In isobutene; tert-butyl alcohol;

Reference yield: 80.6%

cyclopentanecarboxylic acid (3400-45-1) + isobutene (115-11-7,15220-85-6) + tert-butyl alcohol (75-65-0) → 1,1-dimethylethyl cyclopentanecarboxylate (87661-18-5)

Guidance literature:

With sulfuric acid; at -78 - 20 ℃; sealed flask;

Reference yield: 47.0%

cyclopentanecarboxylic acid (3400-45-1) + tert-butyl alcohol (75-65-0) → 1,1-dimethylethyl cyclopentanecarboxylate (87661-18-5)

Guidance literature:

With sulfuric acid; isobutene; for 96h; Ambient temperature;

DOI:10.1021/jm00041a026

upstream raw materials:

2-Chlorocyclohexanone

sodium t-butanolate

Cyclopentanecarboxylic acid chloride

tert-butyl alcohol

Downstream raw materials:

tert-butyl (1R,2S)-2-[N-benzyl-N-(α-methylbenzyl)amino]cyclopentane-1-carboxylate

tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclopentanecarboxylate

(1S,2R,αR)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclopentanecarboxylate

(1R,2R)-2-aminocyclopentanecarboxylic acid hydrochloride

Refernces

• 1、 -. "AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN". Page/Page column 18. . Retrieved 2011/06/19.
• 2、 -. "Mercaptocycloacyl aminoacid endopeptidase inhibitors". . . Retrieved 2008/06/13.