C₁₇H₁₅BrN₂

Base Information

• Chemical Name: C₁₇H₁₅BrN₂
• CAS No.: 1422378-47-9
• Molecular Formula: C₁₇H₁₅BrN₂
• Molecular Weight: 327.224
• Mol file: 1422378-47-9.mol

Synonyms:

Chemical Property of C₁₇H₁₅BrN₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₅BrN₂

There total 3 articles about C₁₇H₁₅BrN₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

6-methyl-8-bromoquinoline (84839-95-2) + 2-bromo-p-toluidine (583-68-6) → C17H15BrN2 (1422378-47-9)

Guidance literature:

With palladium diacetate; sodium tert-pentoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 115 ℃; for 48h; Glovebox; Inert atmosphere;

DOI:10.1021/ja311682c

Reference yield:

p-toluidine (106-49-0,12221-03-3) → C17H15BrN2 (1422378-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / acetonitrile / 3.5 h / 0 - 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; sodium tert-pentoxide / toluene / 48 h / 115 °C / Glovebox; Inert atmosphere

With N-Bromosuccinimide; palladium diacetate; sodium tert-pentoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; acetonitrile;

DOI:10.1021/ja311682c

Reference yield:

2-bromo-p-toluidine (583-68-6) → C17H15BrN2 (1422378-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; sulfuric acid / 1.05 h / 0 - 140 °C / Schlenk technique

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; sodium tert-pentoxide / toluene / 48 h / 115 °C / Glovebox; Inert atmosphere

With sulfuric acid; palladium diacetate; sodium tert-pentoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium iodide; In toluene;

DOI:10.1021/ja311682c

upstream raw materials:

2-bromo-p-toluidine

6-methyl-8-bromoquinoline

p-toluidine

Downstream raw materials:

C₂₃H₃₀N₂Si

Refernces