Technology Process of isoquinoline-5,8-diaMine
There total 5 articles about isoquinoline-5,8-diaMine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 4h;
under 1551.44 Torr;
Ambient temperature;
DOI:10.1016/S0960-894X(99)00152-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 87 percent / hydroxylamine hydrochloride; NaOH / aq. ethanol; methanol / 1.5 h / 50 - 60 °C
2: 95 percent / H2 / Pd-C / aq. ethanol / 2 h / 1551.44 Torr
With
sodium hydroxide; hydroxylamine hydrochloride; hydrogen;
palladium on activated charcoal;
In
methanol; ethanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 86 percent / conc. H2SO4, KNO3 / 6 h / 50 °C
2: 79 percent / activated carbon, FeCl3*6H2O, hydrazine / methanol / 16 h / Heating
3: 1.) Na2CO3, diazotized sulfanilic acid, 2.) sodium hydroxide, sodium dithionite / 1.) AcOH, 7-9 deg C, 30 min, 2.) water, 60 deg C, 30 min
With
sodium hydroxide; sodium dithionite; 4-sulfobenzenediazonium; sulfuric acid; iron(III) chloride; sodium carbonate; pyrographite; potassium nitrate; hydrazine;
In
methanol;
DOI:10.1021/jo00361a014
