Butanoic acid, 3-oxo-, 3-phenylpropyl ester

Base Information

• Chemical Name: Butanoic acid, 3-oxo-, 3-phenylpropyl ester
• CAS No.: 113778-34-0
• Molecular Formula: C13H16O3
• Molecular Weight: 220.268
• Mol file: 113778-34-0.mol

Synonyms:

Chemical Property of Butanoic acid, 3-oxo-, 3-phenylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanoic acid, 3-oxo-, 3-phenylpropyl ester

There total 5 articles about Butanoic acid, 3-oxo-, 3-phenylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-Phenyl-1-propanol (122-97-4) + acetoacetic acid methyl ester (105-45-3) → 3-phenylpropyl-3-oxo butanoate (113778-34-0)

Guidance literature:

sulfated tin oxide; In ethyl acetate; toluene; Petroleum ether;

Reference yield: 94.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 3-Phenyl-1-propanol (122-97-4) → 3-phenylpropyl-3-oxo butanoate (113778-34-0)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo961607u

Reference yield: 87.0%

3-Phenyl-1-propanol (122-97-4) + 2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) → 3-phenylpropyl-3-oxo butanoate (113778-34-0)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 150 ℃; for 2h;

DOI:10.1007/s12272-011-0902-9

upstream raw materials:

4-methyleneoxetan-2-one

3-Phenyl-1-propanol

ethyl acetoacetate

acetoacetic acid methyl ester

Downstream raw materials:

3-phenyl-1-propyl diazoacetate

di(phenylpropyl) 4-(4-chloro-1H-imidazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

di(phenylpropyl) 4-(5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

iso-propyl, phenpropyl-1,4-dihydro-2,6-dimethyl-4-[2-methylthio-1-(phenylamino)-1H-imidazole-5-yl]-3,5-pyridinedicarboxylate

Refernces

• 1、 Balaji,Chanda, Bhanu M.. "Simple and high yielding syntheses of β-keto esters catalysed by zeolites". . p. 13237 - 13252. Retrieved 1998.
• 2、 Iman, Maryam,Davood, Asghar,Nematollahi, Ali Reza,Dehpoor, Ahmad Rerza,Shafiee, Abbas. "Design and synthesis of new 1,4-dihydropyridines containing 4(5)-chloro-5(4)-imidazolyl substituent as a novel calcium channel blocker". experimental part. p. 1417 - 1426. Retrieved 2012/05/04.
• 3、 -. "Process for the transesterification of keto esters using solid acids as catalysts". . . Retrieved 2008/06/13.