Technology Process of rel-(1R,4R)-cis-4-<(tert-butyldiphenylsilyl)oxy>-2-(phenylsulphonyl)-1-<((tetrahydropyran-2'-yl)oxy)methyl>-2-cyclopentene
There total 2 articles about rel-(1R,4R)-cis-4-<(tert-butyldiphenylsilyl)oxy>-2-(phenylsulphonyl)-1-<((tetrahydropyran-2'-yl)oxy)methyl>-2-cyclopentene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH, 2.) n-BuLi / 1.) THF, DMF, 0 deg C, 15 min, RT, 1 h, 2.) THF, -78 deg C, 10 min
2: 1.) n-butyllithium, 2.) copper(I)bromide-dimethyl sulfide complex, lithium bromide, isopropylmagnesium chloride / 1.) hexane, -78 deg C, 10 min, 2.) THF, -78 deg C, 10 min, 3.) THF, -78 deg C, 5 min, -55 deg C, 30 min
With
n-butyllithium; copper(I) bromide dimethylsulfide complex; isopropylmagnesium chloride; sodium hydride; lithium bromide;
DOI:10.1021/ja00250a029
- Guidance literature:
-
With
n-butyllithium; copper(I) bromide dimethylsulfide complex; isopropylmagnesium chloride; lithium bromide;
Yield given. Multistep reaction;
1.) hexane, -78 deg C, 10 min, 2.) THF, -78 deg C, 10 min, 3.) THF, -78 deg C, 5 min, -55 deg C, 30 min;
DOI:10.1021/ja00250a029
