(1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester

Base Information Edit

Chemical Name:(1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester
CAS No.:1988779-13-0
Molecular Formula:C₁₈H₃₄N₂O₅
Molecular Weight:358.478
Hs Code.:
Mol file:1988779-13-0.mol

(1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester

Synonyms:

Suppliers and Price of (1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester Edit

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester

There total 8 articles about (1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 229613-93-8
(+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate

: 1988779-13-0,316173-29-2
(1S,2S,3S,4R)-methyl 3-((S)-1-amino-2-ethylbutyl)-4-(tert-butoxycarbonylamino)-2-hydroxycyclopentanecarboxylate

Guidance literature:: (+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium hydroxide; In methanol; at -5 - 0 ℃; for 2h; Inert atmosphere;

With ammonia; ammonium chloride; sodium nitrite; at 20 ℃; for 16h; Concentration; Reagent/catalyst; Time;
DOI:10.1080/00397911.2012.729279

Reference yield:

: (3aR,4R,6R,6aS)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1'-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopentano[d]isoxazole-6-carboxylic acid methyl ester

: 1988779-13-0,316173-29-2
(1S,2R,3S,4R,1'S)-3-[(1-amino-2'-ethyl)butyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxycyclopentane-1-carboxylic acid methyl ester

Guidance literature:: (3aR,4R,6R,6aS)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1'-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopentano[d]isoxazole-6-carboxylic acid methyl ester; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium hydroxide; In methanol; at -10 - 5 ℃; for 2.16667h;

With ammonium hydroxide; ammonium chloride; sodium nitrite; In methanol; at 20 ℃; for 10h;

Reference yield:

: 79200-56-9
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one

: 1988779-13-0,316173-29-2
(1S,2S,3S,4R)-methyl 3-((S)-1-amino-2-ethylbutyl)-4-(tert-butoxycarbonylamino)-2-hydroxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 5 h / 20 °C / Reflux

2.1: sodium carbonate / hexane; water / 8 h / 20 °C

3.1: sodium hypochlorite / dichloromethane / 22 h / -10 - 20 °C

4.1: nickel(II) chloride hexahydrate; sodium hydroxide; sodium tetrahydroborate / methanol / 2 h / -5 - 0 °C / Inert atmosphere

4.2: 16 h / 20 °C

With hydrogenchloride; sodium hypochlorite; sodium tetrahydroborate; nickel(II) chloride hexahydrate; sodium carbonate; sodium hydroxide; In methanol; hexane; dichloromethane; water;
DOI:10.1080/00397911.2012.729279