Losartan Methyl Ether

Base Information

• Chemical Name: Losartan Methyl Ether
• CAS No.: 114798-94-6
• Molecular Formula: C23H25ClN6O
• Molecular Weight: 436.93700
• Mol file: 114798-94-6.mol

Synonyms:Losartan Methyl Ether;5-[4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-yl]-1H-tetrazole;

Chemical Property of Losartan Methyl Ether

Chemical Property:

• PSA: 81.51000
• LogP: 4.92090

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: O-Methyl Losartan is an impurity of Losartan (L470500), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Technology Process of Losartan Methyl Ether

There total 3 articles about Losartan Methyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-butyl-4-chloro-5-(methoxymethyl)-1-[[2'-[(triphenylmethyl)tetrazole-5-yl]biphenyl-4-yl]methyl]imidazole → 2-butyl-4-chloro-5-(methoxymethyl)-1-[[2'-[tetrazole-5-yl]biphenyl-4-yl]methyl]imidazole (114798-94-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

DOI:10.1002/jlcr.1917

Reference yield:

2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol (124751-00-4) → 2-butyl-4-chloro-5-(methoxymethyl)-1-[[2'-[tetrazole-5-yl]biphenyl-4-yl]methyl]imidazole (114798-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere; Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; mineral oil;

DOI:10.1002/jlcr.1917

Reference yield:

lorsartan (114798-26-4) → 2-butyl-4-chloro-5-(methoxymethyl)-1-[[2'-[tetrazole-5-yl]biphenyl-4-yl]methyl]imidazole (114798-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere; Cooling with ice

3.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/jlcr.1917

upstream raw materials:

2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol

lorsartan

Refernces