(4-Methoxyphenyl)(2,4,6-trimethylphenyl)methanone

Base Information

• Chemical Name: (4-Methoxyphenyl)(2,4,6-trimethylphenyl)methanone
• CAS No.: 1150-51-2
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• European Community (EC) Number: 682-959-0
• DSSTox Substance ID: DTXSID10391097
• Wikidata: Q82188330
• Mol file: 1150-51-2.mol

Synonyms:1150-51-2;mesityl(4-methoxyphenyl)methanone;(4-methoxyphenyl)(2,4,6-trimethylphenyl)methanone;SCHEMBL9726568;DTXSID10391097;AKOS005925456;Benzophenone, 4'-methoxy-2,4,6-trimethyl-;(4-methoxyphenyl)-(2,4,6-trimethyl-phenyl)-methanone;Methanone, (4-methoxyphenyl)(2,4,6-trimethylphenyl)-

Chemical Property of (4-Methoxyphenyl)(2,4,6-trimethylphenyl)methanone

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 254.130679813
• Heavy Atom Count: 19
• Complexity: 292

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C)C(=O)C2=CC=C(C=C2)OC)C

Technology Process of (4-Methoxyphenyl)(2,4,6-trimethylphenyl)methanone

There total 14 articles about (4-Methoxyphenyl)(2,4,6-trimethylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

mesitylboronic acid (5980-97-2) + 1-(4-methoxybenzoyl)piperidine-2,6-dione → (2,4,6-trimethylphenyl)(4-methoxyphenyl)methanone (1150-51-2)

Guidance literature:

With palladium diacetate; sodium carbonate; tricyclohexylphosphine tetrafluoroborate; In 1,4-dioxane; at 120 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b02961

Reference yield: 84.0%

methyl 4-(trifluoromethyl)phenyl ether (402-52-8) + 1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylphenyl)(4-methoxyphenyl)methanone (1150-51-2)

Guidance literature:

methyl 4-(trifluoromethyl)phenyl ether; 1,3,5-trimethyl-benzene; With boron tribromide; In dichloromethane; at 25 ℃; for 3h; Inert atmosphere;

With methanol; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.202001816

Reference yield: 81.0%

4-methoxyphenylboronic acid (5720-07-0) + 1-(2,4,6-trimethylbenzoyl)piperidine-2,6-dione → (2,4,6-trimethylphenyl)(4-methoxyphenyl)methanone (1150-51-2)

Guidance literature:

With palladium diacetate; sodium carbonate; tricyclohexylphosphine tetrafluoroborate; In 1,4-dioxane; at 120 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b02961

upstream raw materials:

4-Bromo-2',4',6'-trimethylbenzophenone

potassium ethoxide

4-methoxy-benzoyl chloride

1,3,5-trimethyl-benzene

Downstream raw materials:

2.4.6-Trimethyl-4'-methoxy-thiobenzophenon

(4-(tert-butyl)phenyl)(mesityl)methanone

Refernces

• 1、 Ikeda, Mai,Matsuzawa, Tsubasa,Morita, Takamoto,Hosoya, Takamitsu,Yoshida, Suguru. "Synthesis of Diverse Aromatic Ketones through C?F Cleavage of Trifluoromethyl Group". supporting information. p. 12333 - 12337. Retrieved 2020/09/09.
• 2、 Parella, Ramarao,Naveen,Kumar, Amit,Babu, Srinivasarao Arulananda. "Catalytic Friedel-Crafts acylation: Magnetic nanopowder CuFe 2O4 as an efficient and magnetically separable catalyst". . p. 1738 - 1742. Retrieved 2013/03/28.