Technology Process of 1-(3-benzyloxy-1-adamantyl)ethanol
There total 5 articles about 1-(3-benzyloxy-1-adamantyl)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanol; sodium tetrahydroborate; 1,1,1-trichloroethane; (1S,2S)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]-1,2-bis(2,4,6-trimethylphenyl)ethylenediaminatocobalt(II);
In
tetrahydrofuran;
at -20 - 0 ℃;
for 24.3333h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1246/cl.2012.780
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: water; potassium hydroxide / ethanol / 2 h / Inert atmosphere; Reflux
2.1: diethyl ether / 4.5 h / 0 - 20 °C / Inert atmosphere
2.2: Inert atmosphere; Cooling with ice
3.1: methanol; sodium tetrahydroborate; (1S,2S)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]-1,2-bis(2,4,6-trimethylphenyl)ethylenediaminatocobalt(II); 1,1,1-trichloroethane / tetrahydrofuran / 24.33 h / -20 - 0 °C / Inert atmosphere
With
methanol; sodium tetrahydroborate; 1,1,1-trichloroethane; (1S,2S)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]-1,2-bis(2,4,6-trimethylphenyl)ethylenediaminatocobalt(II); water; potassium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1246/cl.2012.780
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether / 4.5 h / 0 - 20 °C / Inert atmosphere
1.2: Inert atmosphere; Cooling with ice
2.1: methanol; sodium tetrahydroborate; (1S,2S)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]-1,2-bis(2,4,6-trimethylphenyl)ethylenediaminatocobalt(II); 1,1,1-trichloroethane / tetrahydrofuran / 24.33 h / -20 - 0 °C / Inert atmosphere
With
methanol; sodium tetrahydroborate; 1,1,1-trichloroethane; (1S,2S)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]-1,2-bis(2,4,6-trimethylphenyl)ethylenediaminatocobalt(II);
In
tetrahydrofuran; diethyl ether;
DOI:10.1246/cl.2012.780