C₆₃H₉₁N₉O₆Si₂

Base Information

• Chemical Name: C₆₃H₉₁N₉O₆Si₂
• CAS No.: 154920-50-0
• Molecular Formula: C₆₃H₉₁N₉O₆Si₂
• Molecular Weight: 1126.64
• Mol file: 154920-50-0.mol

Synonyms:

Chemical Property of C₆₃H₉₁N₉O₆Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₃H₉₁N₉O₆Si₂

There total 18 articles about C₆₃H₉₁N₉O₆Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

isobutyryl chloride (79-30-1) + 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-<4,7,10,13-tetrakis(phenylmethyl)-4,7,10,13-tetraazatridec-1-yl>-2'-deoxyguanosine (154920-38-4) → C63H91N9O6Si2 (154920-50-0)

Guidance literature:

With pyridine; triethylamine; for 12h; Ambient temperature;

DOI:10.1002/jhet.5570300532

Reference yield:

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine (90914-08-2) → C63H91N9O6Si2 (154920-50-0)

Guidance literature:

Multi-step reaction with 15 steps

1: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

2: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

3: magnesium sulfate / methanol / 4 h / Ambient temperature

4: NaBH₄ / methanol / Ambient temperature

5: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

6: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

7: magnesium sulfate / methanol / 4 h / Ambient temperature

8: NaBH₄ / methanol / Ambient temperature

9: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

10: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

11: magnesium sulfate / methanol / 4 h / Ambient temperature

12: NaBH₄ / methanol / Ambient temperature

13: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

14: 60 percent / 2-methoxy-ethanol / 12 h / 80 °C

15: 88 percent / pyridine, triethylamine / 12 h / Ambient temperature

With pyridine; potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; triethylamine; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; 2-methoxy-ethanol; acetonitrile;

DOI:10.1002/jhet.5570300532

Reference yield:

benzaldehyde (100-52-7) → C63H91N9O6Si2 (154920-50-0)

Guidance literature:

Multi-step reaction with 13 steps

1: magnesium sulfate / methanol / 4 h / Ambient temperature

2: NaBH₄ / methanol / Ambient temperature

3: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

4: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

5: magnesium sulfate / methanol / 4 h / Ambient temperature

6: NaBH₄ / methanol / Ambient temperature

7: 85 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

8: 79 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

9: magnesium sulfate / methanol / 4 h / Ambient temperature

10: NaBH₄ / methanol / Ambient temperature

11: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

12: 60 percent / 2-methoxy-ethanol / 12 h / 80 °C

13: 88 percent / pyridine, triethylamine / 12 h / Ambient temperature

With pyridine; potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; triethylamine; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; 2-methoxy-ethanol; acetonitrile;

DOI:10.1002/jhet.5570300532

upstream raw materials:

isobutyryl chloride

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-<4,7,10,13-tetrakis(phenylmethyl)-4,7,10,13-tetraazatridec-1-yl>-2'-deoxyguanosine

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine

benzaldehyde

Downstream raw materials:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-6-O-(phenylmethyl)-N-<15-methyl-14-oxo-4,7,10,13-tetrakis(phenylmethyl)-4,7,10,13-tetraazahexadec-1-yl>-2'-deoxyguanosine

Refernces