3-Acetyl RocuroniuM BroMide

Base Information

• Chemical Name: 3-Acetyl RocuroniuM BroMide
• CAS No.: 122483-73-2
• Molecular Formula: Br*C₃₄H₅₅N₂O₅
• Molecular Weight: 651.725
• Mol file: 122483-73-2.mol

Synonyms:

Chemical Property of 3-Acetyl RocuroniuM BroMide

Chemical Property:

• Melting Point: >165°C (dec.)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-AcetylRocuroniumBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Acetyl Rocuronium Bromide is an impuritiy of Rocuronium bromide (R639500), an aminosteroid and a competitive neuromuscular blocker.

Technology Process of 3-Acetyl RocuroniuM BroMide

There total 5 articles about 3-Acetyl RocuroniuM BroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3-hydroxy-17-acetoxyandrostane (119302-24-8) → Br(1-)*C32H53N2O3(1+) (1190105-65-7) + Br(1-)*C34H55N2O5(1+) (122483-73-2) + rocuronium bromide

Guidance literature:

allyl bromide; With sodium carbonate; In dichloromethane; at 20 ℃; for 0.5h;

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3-hydroxy-17-acetoxyandrostane; In dichloromethane; at 40 ℃; for 22h; Product distribution / selectivity;

Reference yield: 100.0%

allyl bromide (106-95-6) → Br(1-)*C34H55N2O5(1+) (122483-73-2) + rocuronium bromide

Guidance literature:

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3-hydroxy-17-acetoxyandrostane; With sodium carbonate; In dichloromethane; for 0.0833333h;

allyl bromide; In dichloromethane; at 32 - 35 ℃; for 24h; Product distribution / selectivity;

Reference yield:

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane (119302-22-6) → 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(4-morpholinyl)-androstan-16-yl]-1-(2-propenyl)pyrrolidinium bromide (122483-73-2)

Guidance literature:

upstream raw materials:

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

allyl bromide

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3-hydroxy-17-acetoxyandrostane

Refernces

• 1、 -. "Novel 2β-morpholino-androstane derivatives". . . Retrieved 2008/06/13.