Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(phenylamino)-

Base Information

• Chemical Name: Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(phenylamino)-
• CAS No.: 1158-04-9
• Molecular Formula: C12H12ClN7O
• Molecular Weight: 305.727
• Mol file: 1158-04-9.mol

Synonyms:

Chemical Property of Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(phenylamino)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(phenylamino)-

There total 4 articles about Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(phenylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

guanidine hydrochloride (50-01-1) + 3-amino-5-anilino-6-chloro-pyrazine-2-carboxylic acid methyl ester (1837-82-7) → C12H12ClN7O (1158-04-9)

Guidance literature:

guanidine hydrochloride; With sodium methylate; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

3-amino-5-anilino-6-chloro-pyrazine-2-carboxylic acid methyl ester; In methanol; Reflux; Inert atmosphere;

DOI:10.1080/09168451.2015.1010479

Reference yield:

N-(3-Amino-5,6-dichloro-pyrazine-2-carbonyl)-guanidine (76599-75-2) + aniline (62-53-3) → C12H12ClN7O (1158-04-9)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 80 - 120 ℃;

DOI:10.1016/j.bmcl.2009.03.029

Reference yield:

aniline (62-53-3) + methyl 6-amino-2,3-dichloropyrazine-5-carboxylate (1458-18-0) → C12H12ClN7O (1158-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropyl alcohol / 2 h / Reflux

2.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

2.2: Reflux; Inert atmosphere

With sodium methylate; In methanol; isopropyl alcohol;

DOI:10.1080/09168451.2015.1010479

upstream raw materials:

N-(3-Amino-5,6-dichloro-pyrazine-2-carbonyl)-guanidine

aniline

methyl 6-amino-2,3-dichloropyrazine-5-carboxylate

guanidine hydrochloride

Refernces

• 1、 Kuduk, Scott D.,Di Marco, Christina N.,Chang, Ronald K.,DiPardo, Robert M.,Cook, Sean P.,Cato, Matthew J.,Jovanovska, Aneta,Urban, Mark O.,Leitl, Michael,Spencer, Robert H.,Kane, Stefanie A.,Bilodeau, Mark T.,Hartman, George D.,Bock, Mark G.. "Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)". scheme or table. p. 2514 - 2518. Retrieved 2009/12/25.