Technology Process of Propanedioic acid, methylphenyl-, monomethyl ester, (R)-
There total 13 articles about Propanedioic acid, methylphenyl-, monomethyl ester, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methyl-2-phenylmalonic acid dimethyl ester;
In
dimethyl sulfoxide;
at 20 ℃;
for 96h;
pH=8;
aq. phosphate buffer;
Enzymatic reaction;
With
hydrogenchloride;
In
water; dimethyl sulfoxide;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/jo902584r
- Guidance literature:
-
hydratropic acid;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 2h;
methyl chloroformate;
In
tetrahydrofuran; hexane;
at -78 ℃;
DOI:10.1021/ol0347803
- Guidance literature:
-
2-methyl-2-phenylmalonic acid dimethyl ester;
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 20 - 25 ℃;
for 2h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=2;
Inert atmosphere;
DOI:10.1021/ja512524j
