Technology Process of 3-epimaytansinol 3-phenylacetate
There total 6 articles about 3-epimaytansinol 3-phenylacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1248/cpb.32.3441
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3.45 mg / NaBH4 / methanol / 0.5 h / Ambient temperature
2: 5.32 mg / 2N HCl / methanol; H2O / 2 h / Ambient temperature
3: 4.32 mg / 4-dimethylaminopyridine, dicyclohexyl carbodiimide / CH2Cl2 / 0.5 h / Ambient temperature
With
hydrogenchloride; dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide;
In
methanol; dichloromethane; water;
DOI:10.1248/cpb.32.2773
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 216 mg / trifluoroacetic acid / 3 h / Ambient temperature
2: 134 mg / NaOAc, pyridinium chlorochromate / CH2Cl2 / 48 h / 39 °C
3: 3.45 mg / NaBH4 / methanol / 0.5 h / Ambient temperature
4: 5.32 mg / 2N HCl / methanol; H2O / 2 h / Ambient temperature
5: 4.32 mg / 4-dimethylaminopyridine, dicyclohexyl carbodiimide / CH2Cl2 / 0.5 h / Ambient temperature
With
hydrogenchloride; dmap; sodium tetrahydroborate; sodium acetate; dicyclohexyl-carbodiimide; pyridinium chlorochromate;
In
methanol; dichloromethane; water; trifluoroacetic acid;
DOI:10.1248/cpb.32.2773