(S)-Butyl-⁽²⁾-isothiocyanat

Base Information

• Chemical Name: (S)-Butyl-⁽²⁾-isothiocyanat
• CAS No.: 116724-11-9
• Molecular Formula: C₅H₉NS
• Molecular Weight: 115.199
• Mol file: 116724-11-9.mol

Synonyms:

Chemical Property of (S)-Butyl-⁽²⁾-isothiocyanat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Butyl-⁽²⁾-isothiocyanat

There total 11 articles about (S)-Butyl-⁽²⁾-isothiocyanat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

SEC-BUTYLAMINE (33966-50-6) + di-2-pyridyl thionocarbonate (96989-50-3) → 2-hydroxypyridin (142-08-5) + sec-butyl isothiocyanate (116724-11-9,623-45-0,4426-79-3,116724-12-0)

Guidance literature:

In dichloromethane; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)98578-2

Reference yield: 71.0%

(+/-)sec-butyl isocyanide (14069-89-7) → sec-butyl isothiocyanate (116724-11-9,623-45-0,4426-79-3,116724-12-0)

Guidance literature:

With selenium; sulfur; triethylamine; In tetrahydrofuran; for 3h; Heating;

DOI:10.1016/0040-4039(91)80817-P

Reference yield: 62.0%

carbon disulfide (75-15-0,12122-00-8) + SEC-BUTYLAMINE (33966-50-6) → sec-butyl isothiocyanate (116724-11-9,623-45-0,4426-79-3,116724-12-0)

Guidance literature:

carbon disulfide; SEC-BUTYLAMINE; In tetrahydrofuran; at 0 - 5 ℃; for 3h;

With CYANAMID; triethylamine; In tetrahydrofuran; at 40 ℃; for 3h;

upstream raw materials:

carbon disulfide

SEC-BUTYLAMINE

di-2-pyridyl thionocarbonate

(+/-)sec-butyl isocyanide

Downstream raw materials:

N_.N'-di-(sec-butyl)-thiourea

SEC-BUTYLAMINE

(S)-2-aminobutane

4-sec-butyl-thiosemicarbazide

Refernces

• 1、 Yamamoto, Tamotsu,Sugiyama, Susumu,Akimoto, Kenji,Hayashi, Kiyoshi. "ONE-POT SYNTHESIS OF ISOTHIOCYANATES FROM PRIMARY AMINES SYNTHESIS USING CYANAMIDE". . p. 346 - 349. Retrieved 2007/10/03.
• 2、 Trofimov, B. A.,Nedolya, N. A.,Gerasimova, V. V.,Voronkov, M. G.. "NEW METHOD FOR SYNTHESIS OF ISOTHIOCYANATES". . p. 1805 - 1806. Retrieved 2007/10/02.