1-methoxy-12-norherbertene

Base Information

• Chemical Name: 1-methoxy-12-norherbertene
• CAS No.: 103412-35-7
• Molecular Formula: C₁₅H₂₂O
• Molecular Weight: 218.339
• Mol file: 103412-35-7.mol

Synonyms:

Chemical Property of 1-methoxy-12-norherbertene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-12-norherbertene

There total 8 articles about 1-methoxy-12-norherbertene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,14-dihydroxyherbertene (86996-96-5) → 1-methoxy-12-norherbertene (103412-35-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) triphenyl phosphite methiodide, 2.) 5percent aqeous sodium tiosulphate / 1.) HMPA, 3.5 h, room temperature

2: 17 mg / AlCl₃ / 6 h / ice-bath

3: 12 percent / W-4 Raney nickel / ethanol / 1.5 h / Heating

4: 263 mg / potassium carbonate / acetone / 6 h / Heating

5: 159 mg / manganese dioxide, 30percent sulphuric acid / 8.5 h / 62 °C

6: 107 mg / 10percent palladium / 1.5 h / 200 - 210 °C

With manganese(IV) oxide; aluminium trichloride; triphenyl phosphite methiodide; sulfuric acid; potassium carbonate; sodium thiosulfate; W-4 Raney nickel; palladium; In ethanol; acetone;

Reference yield:

(-)-herbertenolide (86996-94-3) → 1-methoxy-12-norherbertene (103412-35-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 23 mg / LiAlH₄ / diethyl ether / 2 h / ice-bath

2: 1.) triphenyl phosphite methiodide, 2.) 5percent aqeous sodium tiosulphate / 1.) HMPA, 3.5 h, room temperature

3: 17 mg / AlCl₃ / 6 h / ice-bath

4: 12 percent / W-4 Raney nickel / ethanol / 1.5 h / Heating

5: 263 mg / potassium carbonate / acetone / 6 h / Heating

6: 159 mg / manganese dioxide, 30percent sulphuric acid / 8.5 h / 62 °C

7: 107 mg / 10percent palladium / 1.5 h / 200 - 210 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; aluminium trichloride; triphenyl phosphite methiodide; sulfuric acid; potassium carbonate; sodium thiosulfate; W-4 Raney nickel; palladium; In diethyl ether; ethanol; acetone;

Reference yield:

4-methyl-2-[(1S)-1,2,2-trimethylcyclopentyl]phenol (81784-10-3) → 1-methoxy-12-norherbertene (103412-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 263 mg / potassium carbonate / acetone / 6 h / Heating

2: 159 mg / manganese dioxide, 30percent sulphuric acid / 8.5 h / 62 °C

3: 107 mg / 10percent palladium / 1.5 h / 200 - 210 °C

With manganese(IV) oxide; sulfuric acid; potassium carbonate; palladium; In acetone;

upstream raw materials:

1-methoxy-12-oxoherbertene

4-methyl-2-[(1S)-1,2,2-trimethylcyclopentyl]phenol

1,14-epoxyherbertene

1,14-dihydroxyherbertene

Downstream raw materials:

methyl 2-methoxy-5-nitrobenzoate

Refernces