Technology Process of C28H29N5O2S
There total 16 articles about C28H29N5O2S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jm301039c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 °C
2: isopropyl alcohol / hexane / Resolution of racemate
3: potassium carbonate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane / water; tert-butyl alcohol / 1 h / 60 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C
5: copper diacetate; triethylamine / dichloromethane / 48 h / 20 °C / Molecular sieve
6: trifluoroacetic acid / dichloromethane / 20 °C
With
dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane; tetrabutyl ammonium fluoride; copper diacetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol;
3: |Suzuki Coupling / 5: |Suzuki Coupling;
DOI:10.1021/jm301039c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane / water; tert-butyl alcohol / 1 h / 60 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C
3: copper diacetate; triethylamine / dichloromethane / 48 h / 20 °C / Molecular sieve
4: trifluoroacetic acid / dichloromethane / 20 °C
With
dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane; tetrabutyl ammonium fluoride; copper diacetate; potassium carbonate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
1: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1021/jm301039c