NHS-DTP

Base Information

• Chemical Name: NHS-DTP
• CAS No.: 123861-58-5
• Molecular Formula: C₁₃H₁₃NO₄S₂
• Molecular Weight: 311.383
• Mol file: 123861-58-5.mol

Synonyms:

Chemical Property of NHS-DTP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NHS-DTP

There total 2 articles about NHS-DTP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyldisulfane (882-33-7) → NHS-DTP (123861-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 56.6 percent / aq. NaOH / diethyl ether; methanol / 20 h / 20 °C

2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 2 h

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; diethyl ether; dichloromethane;

DOI:10.1021/jm060319f

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-phenyldithio-propanoic acid (3312-96-7) → NHS-DTP (123861-58-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h;

DOI:10.1021/jm060319f

Reference yield: 62.0%

NHS-DTP (123861-58-5) + s-DBCO-amine + 2-hydroxyethanethiol (60-24-2) → s-DBCO-disulfaneyl ethanol

Guidance literature:

NHS-DTP; sulfo-DBCO-NH₂; With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

2-hydroxyethanethiol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3-phenyldithio-propanoic acid

diphenyldisulfane

Downstream raw materials:

N-methyl-N-(3-phenyldithio-propanoyl)-L-alanine

Refernces