Velpatasvir Co Povidone

Base Information

• Chemical Name: Velpatasvir Co Povidone
• CAS No.: 1844064-96-5
• Molecular Formula: C₃₉H₄₅N₇O₅
• Molecular Weight: 691.83
• Mol file: 1844064-96-5.mol

Synonyms:

Chemical Property of Velpatasvir Co Povidone

Chemical Property:

• Boiling Point: 1024.8±65.0 °C(Predicted)
• PKA: 11.22±0.46(Predicted)
• Density: 1.284±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Velpatasvir Co Povidone

There total 33 articles about Velpatasvir Co Povidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

C39H45N7O5*(x)H3O4P → (2S,4S)-2-[5-(2-{(2S,4S)-1-{N-(methoxycarbonyl)-L-valyl}-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromene[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine (1844064-96-5)

Guidance literature:

With ammonium hydroxide; In dichloromethane; water; for 0.166667h;

Reference yield:

tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate (1378391-45-7) → (2S,4S)-2-[5-(2-{(2S,4S)-1-{N-(methoxycarbonyl)-L-valyl}-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromene[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine (1844064-96-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; for 2h;

Reference yield:

C39H45N7O5*3H3O4P → C39H45N7O5 (1844064-96-5)

Guidance literature:

With ammonium hydroxide; In dichloromethane; water; for 0.75h;

upstream raw materials:

tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate

(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid

Downstream raw materials:

methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Refernces

• 1、 -. "Deuterated antiviral active compounds for hepatitis C viruses". . . Retrieved 2018/04/01.
• 2、 -. "PROCESSES FOR PREPARING ANTIVIRAL COMPOUNDS". Paragraph 0593. . Retrieved 2015/12/30.