Technology Process of C12H15ClN2O
There total 6 articles about C12H15ClN2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C19H19ClN2O3; methyl iodide;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
With
trifluoroacetic acid;
at 50 ℃;
DOI:10.1016/j.bmcl.2011.02.009
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate; cobalt(II) chloride / methanol / 0.33 h / 100 °C / Microwave irradiation
2.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
3.2: 50 °C
With
sodium tetrahydroborate; sodium hydride; sodium hydrogencarbonate; cobalt(II) chloride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.02.009
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / 20 °C
2.1: sodium methylate / methanol / 20 °C
3.1: potassium tert-butylate / tert-butyl alcohol / 20 °C
4.1: hydrogenchloride / diethyl ether; water / 4 h / 20 °C
5.1: sodium tetrahydroborate; cobalt(II) chloride / methanol / 0.33 h / 100 °C / Microwave irradiation
6.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
7.2: 50 °C
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium tert-butylate; sodium methylate; sodium hydride; sodium hydrogencarbonate; cobalt(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2011.02.009
