(E)-N~5~-[amino(nitroamino)methylidene]ornithine

Base Information

• Chemical Name: (E)-N~5~-[amino(nitroamino)methylidene]ornithine
• CAS No.: 13855-78-2
• Molecular Formula: C₆H₁₃N₅O₄
• Molecular Weight: 219.2
• Mol file: 13855-78-2.mol

Synonyms:

Chemical Property of (E)-N~5~-[amino(nitroamino)methylidene]ornithine

Chemical Property:

• Vapor Pressure: 7.81E-10mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N~5~-[amino(nitroamino)methylidene]ornithine

There total 11 articles about (E)-N~5~-[amino(nitroamino)methylidene]ornithine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-arginine (74-79-3,25212-18-4) → N-nitro-L-arginine (2149-70-4,13855-78-2,38733-00-5)

Guidance literature:

With nitric acid;

Reference yield:

L-arginine hydrochloride (1119-34-2) → N-nitro-L-arginine (2149-70-4,13855-78-2,38733-00-5)

Guidance literature:

With sulfuric acid; sulfur trioxide; nitric acid; Nitrogen dioxide;

Reference yield:

Boc-Arg(NO2)-OH (2188-18-3) → N-nitro-L-arginine (2149-70-4,13855-78-2,38733-00-5)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1246/bcsj.38.1148

upstream raw materials:

D-arginine

L-arginine

Boc-Arg(NO₂)-OH

L-arginine hydrochloride

Downstream raw materials:

Z-D-Arg(NO₂)-OH

N^ω-nitro-L-arginine benzyl ester

N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxopropan-2-yl)-4-methoxybenzamide

(S)-4-bromo-N-(1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-yl)-3-nitrobenzamide

Refernces

• 1、 Pfeiffer, Silvia,Leopold, Eva,Schmidt, Kurt,Brunner, Friedrich,Mayer, Bernd. "Inhibition of nitric oxide synthesis by N(G)-nitro-L-arginine methyl ester (L-NAME): Requirement for bioactivation to the free acid, N(G)-nitro-L-arginine". . p. 1433 - 1440. Retrieved 1996.
• 2、 Inouye,K.. "-". . p. 1148 - 1157. Retrieved 1965.
• 3、 Mou, Jiajia,Luan, Yepeng,Chen, Danghui,Wang, Qiang. "Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation". . p. 3015 - 3025. Retrieved 2017/10/06.
• 4、 Mou, Jiajia,Fang, Hao,Jing, Fanbo,Wang, Qiang,Liu, Yingzi,Zhu, Huawei,Shang, Luqing,Wang, Xuejian,Xu, Wenfang. "Design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase N/CD13 inhibitors". scheme or table. p. 4666 - 4673. Retrieved 2009/12/01.