4-methylbenzo[h]quinolin-2(1H)-one

Base Information

• Chemical Name: 4-methylbenzo[h]quinolin-2(1H)-one
• CAS No.: 1210-07-7
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.247
• Mol file: 1210-07-7.mol

Synonyms:

Chemical Property of 4-methylbenzo[h]quinolin-2(1H)-one

Chemical Property:

• Vapor Pressure: 3.16E-08mmHg at 25°C

Purity/Quality:

99%min ^*data from raw suppliers

4-METHYLBENZO(H)QUINOLIN-2(1H)ONE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methylbenzo[h]quinolin-2(1H)-one

There total 5 articles about 4-methylbenzo[h]quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-1-naphthyl-3-oxobutyramide (86-83-9) → 4-methyl-2(1H)-benzoquinolinone (1210-07-7)

Guidance literature:

With sulfuric acid; at 95 ℃; for 1h; Inert atmosphere; Industrial scale;

DOI:10.1021/acs.organomet.5b00978

Reference yield: 89.0%

ethyl acetoacetate (141-97-9) + 1-amino-naphthalene (134-32-7) → 4-methyl-2(1H)-benzoquinolinone (1210-07-7)

Guidance literature:

DOI:10.1016/S0022-2860(98)00616-4

Reference yield:

1-amino-naphthalene (134-32-7) → 4-methyl-2(1H)-benzoquinolinone (1210-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / tetrahydrofuran / 26 h / Inert atmosphere; Reflux

2: sulfuric acid / 1 h / 95 °C / Inert atmosphere; Industrial scale

With sulfuric acid; sodium acetate; In tetrahydrofuran;

DOI:10.1021/acs.organomet.5b00978

upstream raw materials:

N-1-naphthyl-3-oxobutyramide

ethyl acetoacetate

1-amino-naphthalene

Downstream raw materials:

4-(trans-2-benzo[h]quinolin-4-yl-vinyl)-N,N-dimethyl-aniline

4-styryl-benzo[h]quinoline

benzo[h]quinoline-4-carboxylic acid

4-methyl-7,8-benzoquinoline

Refernces

• 1、 -. "BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF". . . Retrieved 2016/12/22.