5'-O-<(diethylphosphono)methyl>-2',3'-dideoxycytidine

Base Information

• Chemical Name: 5'-O-<(diethylphosphono)methyl>-2',3'-dideoxycytidine
• CAS No.: 129151-56-0
• Molecular Formula: C₁₄H₂₄N₃O₆P
• Molecular Weight: 361.335
• Mol file: 129151-56-0.mol

Synonyms:

Chemical Property of 5'-O-<(diethylphosphono)methyl>-2',3'-dideoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5'-O-<(diethylphosphono)methyl>-2',3'-dideoxycytidine

There total 1 articles about 5'-O-<(diethylphosphono)methyl>-2',3'-dideoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (p-toluenesulfonyloxymethane)phosphonate (31618-90-3) + 1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-4-methoxypyrimidin-2(1H)-one (129151-50-4) → 5'-O--2',3'-dideoxycytidine (129174-12-5) + 5'-O-<(diethylphosphono)methyl>-2',3'-dideoxycytidine (129151-56-0)

Guidance literature:

With methanol; ammonia; sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, RT, 3 days, 2.) 100 deg C, overnight;

DOI:10.1021/jm00171a023

upstream raw materials:

diethyl (p-toluenesulfonyloxymethane)phosphonate

1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-4-methoxypyrimidin-2(1H)-one

Refernces