Technology Process of 2,8,10-Heptadecatriene-4,6-diyne-1,14-diol
There total 12 articles about 2,8,10-Heptadecatriene-4,6-diyne-1,14-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-Bromosuccinimide / methanol / 1 h / -10 - 25 °C
1.2: 10 h / Reflux
2.1: phosphoric acid / 60 °C
3.1: lithium chloride / tetrahydrofuran / -20 - 25 °C
4.1: phosphorus tribromide; pyridine / diethyl ether / 0.5 h / 0 °C / Reflux
5.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -15 °C
5.2: 1 h / 20 °C
6.1: tetrahydrofuran; diethyl ether / 1 h / -15 °C
7.1: N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 12 h / 25 °C
8.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 25 °C
With
pyridine; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; phosphoric acid; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; acetonitrile;
5.1: |Weinreb Ketone Synthesis / 5.2: |Weinreb Ketone Synthesis / 7.1: |Glaser Coupling;
DOI:10.1016/j.bmc.2015.07.031
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium hydroxide / methanol / 6 h / Reflux
2.1: phosphoric acid / 60 °C
3.1: lithium chloride / tetrahydrofuran / -20 - 25 °C
4.1: phosphorus tribromide; pyridine / diethyl ether / 0.5 h / 0 °C / Reflux
5.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -15 °C
5.2: 1 h / 20 °C
6.1: tetrahydrofuran; diethyl ether / 1 h / -15 °C
7.1: N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 12 h / 25 °C
8.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 25 °C
With
pyridine; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; phosphoric acid; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; lithium chloride; potassium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; acetonitrile;
5.1: |Weinreb Ketone Synthesis / 5.2: |Weinreb Ketone Synthesis / 7.1: |Glaser Coupling;
DOI:10.1016/j.bmc.2015.07.031