N-DESETHYL AMODIAQUINE

Base Information

• Chemical Name: N-DESETHYL AMODIAQUINE
• CAS No.: 37672-04-1
• Molecular Formula: C16H14 Cl N3 O
• Molecular Weight: 299.7549
• Hs Code.: 2933499090
• Mol file: 37672-04-1.mol

Synonyms:desethylamodiaquine;bidesethyl amodiaquine;

Chemical Property of N-DESETHYL AMODIAQUINE

Chemical Property:

• Vapor Pressure: 7.06E-10mmHg at 25°C
• Melting Point: 168-174°C
• Boiling Point: 481°C at 760 mmHg
• PKA: 8.85±0.50(Predicted)
• Flash Point: 244.7°C
• PSA: 57.18000
• Density: 1.406g/cm³
• LogP: 4.91080
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

N-DesethylAmodiaquine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Amodiaquine, an antimalarial

Technology Process of N-DESETHYL AMODIAQUINE

There total 2 articles about N-DESETHYL AMODIAQUINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) + 4‐amino‐2‐(aminomethyl)phenol dihydrochloride (135043-64-0) → 7-chloro-4-(α-amino-4-hydroxy-m-toluidino)quinoline (37672-04-1)

Guidance literature:

In water; at 100 ℃; for 2h; Yield given; pH 4.5-5.0;

DOI:10.1021/jm00144a020

Reference yield:

→ 7-chloro-4-(α-amino-4-hydroxy-m-toluidino)quinoline (37672-04-1)

Guidance literature:

2-(α-Nitromethyl)-4-nitrophenol (I), 1) Zn/H2SO4, 2) 4,7-Dichlorchinolin;

Reference yield: 65.0%

7-chloro-4-(α-amino-4-hydroxy-m-toluidino)quinoline (37672-04-1) + N,N-diethylcarbamyl chloride (88-10-8) → 7-chloro-4-<α--4-hydroxy-m-toluidino>quinoline (79352-91-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; 1.) 28 deg C, 1 h, 2.) reflux, 4 h;

DOI:10.1021/jm00144a020

upstream raw materials:

4,7-dichloroquinoline

4‐amino‐2‐(aminomethyl)phenol dihydrochloride

Downstream raw materials:

7-chloro-4-<α-amino>-4-hydroxy-m-toluidino>quinoline

7-chloro-4-<α--4-hydroxy-m-toluidino>quinoline

Refernces

• 1、 Natarajan,Ngiam Tong Lan. "An alternative method for the synthesis of camoquine.". . p. 1230 - 1231. Retrieved 2007/10/04.