Quinoline, 4-chloro-2-phenyl-, 1-oxide

Base Information

• Chemical Name: Quinoline, 4-chloro-2-phenyl-, 1-oxide
• CAS No.: 1217-74-9
• Molecular Formula: C15H10ClNO
• Molecular Weight: 255.703
• Mol file: 1217-74-9.mol

Synonyms:

Chemical Property of Quinoline, 4-chloro-2-phenyl-, 1-oxide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 4-chloro-2-phenyl-, 1-oxide

There total 4 articles about Quinoline, 4-chloro-2-phenyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-Chloroquinoline N-oxide (4637-59-6) + diphenyliodonium tetrafluoroborate → 4-chloro-2-phenylquinoline 1-oxide (1217-74-9)

Guidance literature:

With eosin; caesium carbonate; p-benzoquinone; In methanol; at -78 - 20 ℃; for 72h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.9b02933

Reference yield: 34.0%

4-Chloroquinoline N-oxide (4637-59-6) + phenyllithium (591-51-5) → 4-chloro-2-phenylquinoline 1-oxide (1217-74-9)

Guidance literature:

4-Chloroquinoline N-oxide; phenyllithium; In tetrahydrofuran; diethyl ether; cyclohexane; at -30 ℃; for 1h;

With 9-fluorenone; In tetrahydrofuran; diethyl ether; cyclohexane; at -30 - 25 ℃; for 1h;

Reference yield:

4-Chloroquinoline N-oxide (4637-59-6) + phenylmagnesium bromide → 4-chloro-2-phenylquinoline 1-oxide (1217-74-9) + 4-chloro-2-phenylquinoline (4979-79-7) + C21H15ClNO (74831-36-0)

Guidance literature:

With lead dioxide; Yield given. Multistep reaction. Yields of byproduct given; 1. THF, r.t., 3h; 2. benzene, 2h;

upstream raw materials:

4-Chloroquinoline N-oxide

phenyllithium

Downstream raw materials:

C₂₁H₁₅ClNO

Refernces

• 1、 Tagawa, Yoshinobu,Nomura, Manami,Yamashita, Hiroyuki,Goto, Yoshinobu,Hamana, Masatomo. "Reaction of quinoline N-oxides with alkyl- and aryllithiums in the presence of oxidant". . p. 2385 - 2397. Retrieved 2007/10/03.