6-BROMOFLAVONE

Base Information

• Chemical Name: 6-BROMOFLAVONE
• CAS No.: 1218-80-0
• Molecular Formula: C15H9BrO2
• Molecular Weight: 301.139
• Hs Code.: 2914700090
• Mol file: 1218-80-0.mol

Synonyms:6-Bromoflavone;

Chemical Property of 6-BROMOFLAVONE

Chemical Property:

• Vapor Pressure: 2.67E-07mmHg at 25°C
• Melting Point: 193-196 °C(lit.)
• Refractive Index: 1.656
• Boiling Point: 421.1 °C at 760 mmHg
• Flash Point: 208.5 °C
• PSA: 30.21000
• Density: 1.54 g/cm³
• LogP: 4.22250

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromoflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMOFLAVONE

There total 44 articles about 6-BROMOFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-phenyl-1-(2'-hydroxy-5'-bromophenyl)-2-propen-1-one (1218-22-0,132972-27-1) → 6-bromoflavone (1218-80-0)

Guidance literature:

With copper(l) iodide; oxygen; at 50 ℃; for 48h; under 760.051 Torr; Ionic liquid;

DOI:10.1039/c1ob06209c

Reference yield: 95.0%

1-(5-bromo-2-hydroxyphenyl)-3-phenyl-1,3-propanedione (5067-24-3) → 6-bromoflavone (1218-80-0)

Guidance literature:

copper dichloride; In ethanol; for 0.0833333h; microwave irradiation;

DOI:10.1016/j.tetlet.2005.07.038

Reference yield: 92.0%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one (20718-17-6) + 5-bromosalicyclaldehyde (1761-61-1) → 6-bromoflavone (1218-80-0)

Guidance literature:

2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one; 5-bromosalicyclaldehyde; With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In 1,2-dichloro-ethane; at 100 ℃; for 6h; Sealed tube; Inert atmosphere;

With sulfuric acid; acetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 3h; Sealed tube; Inert atmosphere;

DOI:10.1177/1747519819867230

upstream raw materials:

Flavanone

6-bromo-2-phenylchroman-4-one

5-bromo-2,β-dimethoxy-chalcone

1-(5-bromo-2-methoxy-phenyl)-3-phenyl-propane-1,3-dione

Downstream raw materials:

2'-phenyl-2,6'-p-phenylene-bis-chromen-4-one

6,6''-biflavone

(E)-6-styrylflavone

(E)-6-(4-methylstyryl)flavone

Refernces

• 1、 Chen, Juncheng,Chiang, Cheng-Ming,He, Gu,Liu, Bo,Liu, Jie,Ouyang, Liang,Tang, Pan,Wang, Guan,Yang, Chengcan,Ye, Tinghong,Zhang, Jifa,Zhang, Jin,Zou, Ling. "Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy". . p. 18025 - 18053. Retrieved 2022/01/03.
• 2、 Cheng, Kang,Chen, Jinkang,Jin, Licheng,Zhou, Jian,Jiang, Xinpeng,Yu, Chuanming. "Rhodium(III)-catalyzed one-pot synthesis of flavonoids from salicylaldehydes and sulfoxonium ylides". . p. 392 - 398. Retrieved 2019/09/03.