(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Base Information

• Chemical Name: (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide
• CAS No.: 1375277-78-3
• Molecular Formula: C₃₀H₃₂N₄O₅
• Molecular Weight: 528.608
• Mol file: 1375277-78-3.mol

Synonyms:

Chemical Property of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

There total 3 articles about (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

mononitro-p-xylene (89-58-7) → (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide (1375277-78-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: nitric acid / sulfuric acid / 2 h / 0 °C

2.1: hydrogen / 15% palladium on carbon / methanol / 40 °C / Inert atmosphere

3.1: tetrahydrofuran / 20 °C

4.1: trichlorophosphate / Reflux

4.2: pH 8 / Cooling with ice

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

5.2: 0.83 h / 0 °C

5.3: pH 2 / Cooling with ice

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

6.2: 2 h / 0 °C

6.3: pH 4 / Cooling with ice

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrogen; nitric acid; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; sulfuric acid; 15% palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2,3-dinitro-p-xylene (711-41-1) → (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide (1375277-78-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogen / 15% palladium on carbon / methanol / 40 °C / Inert atmosphere

2.1: tetrahydrofuran / 20 °C

3.1: trichlorophosphate / Reflux

3.2: pH 8 / Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

4.2: 0.83 h / 0 °C

4.3: pH 2 / Cooling with ice

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

5.2: 2 h / 0 °C

5.3: pH 4 / Cooling with ice

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 15% palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

3,6-dimethylbenzene-1,2-diamine (35975-12-3) → (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-4,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide (1375277-78-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 20 °C

2.1: trichlorophosphate / Reflux

2.2: pH 8 / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

3.2: 0.83 h / 0 °C

3.3: pH 2 / Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

4.2: 2 h / 0 °C

4.3: pH 4 / Cooling with ice

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

mononitro-p-xylene

3,6-dimethylbenzene-1,2-diamine

2,3-dinitro-p-xylene

Refernces