C₃₆H₃₃ClO₁₁S

Base Information

• Chemical Name: C₃₆H₃₃ClO₁₁S
• CAS No.: 1334304-77-6
• Molecular Formula: C₃₆H₃₃ClO₁₁S
• Molecular Weight: 709.17
• Mol file: 1334304-77-6.mol

Synonyms:

Chemical Property of C₃₆H₃₃ClO₁₁S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₃₃ClO₁₁S

There total 7 articles about C₃₆H₃₃ClO₁₁S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4-(hydroxymethyl)phenyl 4-methylbenzene-1-sulfonate (109103-16-4) + 2β-chloropodophyllotoxin → C36H33ClO11S (1334304-77-6)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -15 - 20 ℃; stereoselective reaction;

DOI:10.1016/j.bmcl.2011.07.075

Reference yield:

4-O-tetrahydropyran-2-ylpodophyllotoxin (62318-97-2) → C36H33ClO11S (1334304-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

1.2: 4 h / -78 °C

2.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / -15 - 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.07.075

Reference yield:

4-tosyloxybenzaldehyde (80459-48-9) → C36H33ClO11S (1334304-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 - 5 °C

2: boron trifluoride diethyl etherate / dichloromethane / -15 - 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.07.075

upstream raw materials:

4-O-tetrahydropyran-2-ylpodophyllotoxin

4-tosyloxybenzaldehyde

4-(hydroxymethyl)phenyl 4-methylbenzene-1-sulfonate

4-hydroxy-benzaldehyde

Refernces