Technology Process of PQR620
There total 6 articles about PQR620 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II);
In
1,4-dioxane; water;
at 95 ℃;
for 2h;
Inert atmosphere;
With
hydrogenchloride;
In
1,4-dioxane; water;
at 60 ℃;
Inert atmosphere;
- Guidance literature:
-
With
potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II);
In
1,4-dioxane; water;
at 95 ℃;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b01262
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium diacetate; caesium carbonate; XPhos / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere
1.2: 0.75 h / 80 °C
2.1: N-Bromosuccinimide / tetrahydrofuran / 0 - 20 °C
3.1: tetrahydrofuran / 3 h / 60 °C
4.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 - 20 °C
4.2: 3 h / 60 °C
5.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium phosphate / 1,4-dioxane; water / 95 °C / Inert atmosphere
With
potassium phosphate; N-Bromosuccinimide; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); isopropylmagnesium chloride; palladium diacetate; caesium carbonate; XPhos;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/acs.jmedchem.8b01262
