2-(2-Bromoethoxy)-1,4-dimethylbenzene

Base Information

• Chemical Name: 2-(2-Bromoethoxy)-1,4-dimethylbenzene
• CAS No.: 37136-96-2
• Molecular Formula: C10H13 Br O
• Molecular Weight: 229.117
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID80394919
• Mol file: 37136-96-2.mol

Synonyms:2-(2-bromoethoxy)-1,4-dimethylbenzene;37136-96-2;2-(2-Bromo-ethoxy)-1,4-dimethyl-benzene;2-(2-Bromo-ethoxy)-1,4-dimethylbenzene;SCHEMBL6743557;DTXSID80394919;JBISLHJJABQJNR-UHFFFAOYSA-N;MFCD02030776;STL182768;AKOS000117163;1-(2'-bromoethanoxy) 2,5-dimethylbenzene;CS-0221016;EN300-08152;J-505546;Z56950515

Chemical Property of 2-(2-Bromoethoxy)-1,4-dimethylbenzene

Chemical Property:

• Vapor Pressure: 0.0073mmHg at 25°C
• Boiling Point: 278.2°Cat760mmHg
• Flash Point: 110.1°C
• PSA: 9.23000
• Density: 1.304g/cm³
• LogP: 3.07710
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 228.01498
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Bromoethoxy)-1,4-dimethylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)C)OCCBr

Technology Process of 2-(2-Bromoethoxy)-1,4-dimethylbenzene

There total 3 articles about 2-(2-Bromoethoxy)-1,4-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2,5-Dimethylphenol (95-87-4) + ethylene dibromide (106-93-4) → 2-(2-bromoethoxy)-1,4-dimethylbenzene (37136-96-2)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 72h;

DOI:10.1021/acsmedchemlett.7b00100

Reference yield:

2-(2,5-dimethylphenoxy)ethan-1-ol (93-86-7) → 2-(2-bromoethoxy)-1,4-dimethylbenzene (37136-96-2)

Guidance literature:

With phosphorus tribromide; for 2h; Reflux;

Reference yield:

2,5-Dimethylphenol (95-87-4) → 2-(2-bromoethoxy)-1,4-dimethylbenzene (37136-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; sodium ethanolate / acetone / 48 h / Reflux

2: phosphorus tribromide / 2 h / Reflux

With sodium ethanolate; phosphorus tribromide; potassium carbonate; In acetone;

upstream raw materials:

2,5-Dimethylphenol

ethylene dibromide

2-(2,5-dimethylphenoxy)ethan-1-ol

Downstream raw materials:

R,S-1-[2-(2,5-dimethylphenoxy)ethyl]aminopropan-2-ol

R,S-2-[2-(2,5-dimethylphenoxy)ethyl]aminopropan-1-ol

R,S-2-[2-(2,5-dimethylphenoxy)ethyl]aminobutan-1-ol

R,S-1-[2-(2,5-dimethylphenoxy)ethyl]aminobutan-2-ol

Refernces

• 1、 Waszkielewicz, Anna Maria,Gunia-Krzyzak, Agnieszka,Ceg? A, Marek,Marona, Henryk. "Synthesis and evaluation of anticonvulsant activity of N -(2,5-dimethylphenoxy)-and N-[(2,3,5-trimethylphenoxy)alkyl] aminoalkanols". . p. 89 - 99. Retrieved 2015/02/05.