Technology Process of C27H24Br2O4
There total 9 articles about C27H24Br2O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / Inert atmosphere
2.1: borane-THF; (R)-5-(hydroxydiphenylmethyl)pyrrolidine-2-one / tetrahydrofuran / 5 h / 20 °C
3.1: water; sodium hydroxide / isopropyl alcohol / 1.5 h / 10 - 20 °C
4.1: tetrahydrofuran; diethyl ether / 0.25 h / 0 °C / Inert atmosphere
4.2: 760.05 Torr
5.1: methyl magnesium iodide / diethyl ether / 30 h / 180 °C / Inert atmosphere
6.1: pyridine / 24 h / 20 °C / Inert atmosphere
With
pyridine; methyl magnesium iodide; borane-THF; (R)-5-(hydroxydiphenylmethyl)pyrrolidine-2-one; water; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; isopropyl alcohol; acetone;
2.1: |Itsuno-Corey Reduction;
DOI:10.1002/ejoc.201201112
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium hydroxide / water; acetone / 1 h / Reflux
2.1: phosphorus pentoxide; silica gel
3.1: borane-THF; (R)-5-(hydroxydiphenylmethyl)pyrrolidine-2-one / tetrahydrofuran / 5 h / 20 °C
4.1: water; sodium hydroxide / isopropyl alcohol / 1.5 h / 10 - 20 °C
5.1: tetrahydrofuran; diethyl ether / 0.25 h / 0 °C / Inert atmosphere
5.2: 760.05 Torr
6.1: methyl magnesium iodide / diethyl ether / 30 h / 180 °C / Inert atmosphere
7.1: pyridine / 24 h / 20 °C / Inert atmosphere
With
pyridine; methyl magnesium iodide; borane-THF; phosphorus pentoxide; (R)-5-(hydroxydiphenylmethyl)pyrrolidine-2-one; water; silica gel; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; water; isopropyl alcohol; acetone;
3.1: |Itsuno-Corey Reduction;
DOI:10.1002/ejoc.201201112
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran; diethyl ether / 0.25 h / 0 °C / Inert atmosphere
1.2: 760.05 Torr
2.1: methyl magnesium iodide / diethyl ether / 30 h / 180 °C / Inert atmosphere
3.1: pyridine / 24 h / 20 °C / Inert atmosphere
With
pyridine; methyl magnesium iodide;
In
tetrahydrofuran; diethyl ether;
DOI:10.1002/ejoc.201201112