alpha-chloroanisole

Base Information

• Chemical Name: alpha-chloroanisole
• CAS No.: 6707-01-3
• Molecular Formula: C7H7 Cl O
• Molecular Weight: 142.585
• Mol file: 6707-01-3.mol

Synonyms:Anisole, a-chloro- (6CI,8CI);(Chloromethoxy)benzene; (Phenyloxy)methyl chloride; Chloromethyl phenyl ether;Phenoxymethyl chloride; a-Chloroanisole

Chemical Property of alpha-chloroanisole

Chemical Property:

• Vapor Pressure: 0.464mmHg at 25°C
• Boiling Point: 200.2°C at 760 mmHg
• Flash Point: 81.2°C
• Density: 1.142g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-chloroanisole

There total 18 articles about alpha-chloroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenoxymethyl bis(dimethyl glyoximato)pyridine cobalt(III) → (4-Cl-C6H4OCH2) bis(dimethyl glyoximato)pyridine cobalt(III) + (chloromethoxy)benzene (6707-01-3)

Guidance literature:

With chlorine; In chloroform; addn. of soln. of Cl2 in CHCl3 to soln. of Co-compd. in CHCl3 (darkness, room temp., N2 atmosphere, 45 min); concn., pouring into ether, filtration, washing (ether), chromy. (silica gel, CH2Cl2:MeOH:pyridine 90:9:1 vol/vol);

DOI:10.1016/S0020-1693(00)85262-7

Reference yield: 81.0%

Phenoxyacetyl chloride (701-99-5) → (chloromethoxy)benzene (6707-01-3)

Guidance literature:

With Wilkinson's catalyst; at 170 ℃; for 1h;

DOI:10.1016/0040-4039(95)00562-Q

Reference yield: 77.0%

1-chloro-4-phenoxymethylsulfanyl-benzene (68360-42-9) → (chloromethoxy)benzene (6707-01-3) + 4-chloro-benzenesulfenyl chloride (933-01-7)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; for 0.166667h;

upstream raw materials:

phenoxy-methanesulfonic acid

methoxybenzene

sodium phenoxymethanesulfonate

dibenzoyl peroxide

Downstream raw materials:

C₁₄H₁₄N₂O₄

2-phenoxy-1-(thiophen-2-yl)ethan-1-one

2-phenoxy-1-phenylethanone

3-bromo-β-phenoxystyrene

Refernces

• 1、 Vardhaman, Anil Kumar,Barman, Prasenjit,Kumar, Suresh,Sastri, Chivukula V.,Kumar, Devesh,De Visser, Sam P.. "Mechanistic insight into halide oxidation by non-heme iron complexes. Haloperoxidase versus halogenase activity". . p. 10926 - 10928. Retrieved 2013/11/19.
• 2、 Tanemura, Kiyoshi,Suzuki, Tsuneo,Nishida, Yoko,Horaguchi, Takaaki. "Chlorination of various substrates in subcritical carbon tetrachloride". experimental part. p. 2881 - 2888. Retrieved 2010/06/16.