hydrochloride

Base Information

• Chemical Name: hydrochloride
• CAS No.: 123811-73-4
• Molecular Formula: C7H7NO2.ClH
• Molecular Weight: 173.599
• Hs Code.: 2933399090
• Mol file: 123811-73-4.mol

Synonyms:

Chemical Property of hydrochloride

Chemical Property:

• PSA: 50.19000
• LogP: 1.89020

Purity/Quality:

99% ^*data from raw suppliers

4-methyl-2-Pyridinecarboxylicacidhydrochloride 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hydrochloride

There total 2 articles about hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-Cyano-4-methylpyridin (1620-76-4) → 4-Methyl-pyridine-2-carboxylic acid; hydrochloride (123811-73-4)

Guidance literature:

With hydrogenchloride; for 24h; Heating;

DOI:10.1021/jo00289a058

Reference yield:

4-methylpyridine-1-oxide (1003-67-4) → 4-Methyl-pyridine-2-carboxylic acid; hydrochloride (123811-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylcarbamyl chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: 93 percent / 6 N HCl / 24 h / Heating

With hydrogenchloride; N,N-Dimethylcarbamoyl chloride; In dichloromethane;

DOI:10.1021/jo00289a058

Reference yield: 92.0%

4-Methyl-pyridine-2-carboxylic acid; hydrochloride (123811-73-4) → (+/-)-cis-4-methylpipecolic acid (69081-79-4,69081-80-7,74874-06-9,74892-81-2,79199-63-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; water; at 60 ℃; for 24h; under 3102.9 Torr;

DOI:10.1021/jo00289a058

upstream raw materials:

2-Cyano-4-methylpyridin

4-methylpyridine-1-oxide

Downstream raw materials:

(+/-)-cis-4-methylpipecolic acid

(+/-)-cis-Boc-4-methylpipecolinic acid

Refernces