5'-O-trityl-6,2'-O-cyclouridine

Base Information

• Chemical Name: 5'-O-trityl-6,2'-O-cyclouridine
• CAS No.: 73556-52-2
• Molecular Formula: C₂₈H₂₄N₂O₆
• Molecular Weight: 484.508
• Mol file: 73556-52-2.mol

Synonyms:

Chemical Property of 5'-O-trityl-6,2'-O-cyclouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-trityl-6,2'-O-cyclouridine

There total 3 articles about 5'-O-trityl-6,2'-O-cyclouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

5-iodo-5'-O-trityl-1-(β-D-arabinofuranosyl)uracil (73556-50-0) → 5'-O-trityl-6,2'-O-cyclouridine (73556-52-2)

Guidance literature:

With sodium methylate; for 2h; Heating;

Reference yield:

trityl chloride (76-83-5) → 5'-O-trityl-6,2'-O-cyclouridine (73556-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / pyridine / 48 h / Ambient temperature

2: 40 percent / 1 N MeONa in methanol / 2 h / Heating

With sodium methylate; In pyridine;

Reference yield:

1-β-D-arabinofuranosyl-5-iodouracil (3052-06-0) → 5'-O-trityl-6,2'-O-cyclouridine (73556-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / pyridine / 48 h / Ambient temperature

2: 40 percent / 1 N MeONa in methanol / 2 h / Heating

With sodium methylate; In pyridine;

upstream raw materials:

5-iodo-5'-O-trityl-1-(β-D-arabinofuranosyl)uracil

trityl chloride

1-β-D-arabinofuranosyl-5-iodouracil

Downstream raw materials:

(2R,3R,3aS,9aR)-5-Chloro-3-hydroxy-2-trityloxymethyl-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-c]pyrimidine-6,8-dione

Refernces