methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide

Base Information

• Chemical Name: methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide
• CAS No.: 1333522-26-1
• Molecular Formula: C₁₈H₁₇NO₅S
• Molecular Weight: 359.403
• Mol file: 1333522-26-1.mol

Synonyms:

Chemical Property of methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide

There total 3 articles about methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-2-bromoethane (103-63-9) + methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) → methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide (1333522-26-1)

Guidance literature:

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

1-phenyl-2-bromoethane; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide (6639-62-9) → methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide (1333522-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 55 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

2.2: 20 °C

With sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;

Reference yield:

saccharin sodium salt (128-44-9) → methyl 4-hydroxy-2-(2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide (1333522-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 0.5 h / 60 °C

2.1: sodium methylate / methanol / 55 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

3.2: 20 °C

With sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

saccharin sodium salt

1-phenyl-2-bromoethane

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Refernces