Technology Process of 2α-bromo-3β-hydroxy-5α-H,4,6β-H-11-phenylselenoeudesman-6,13-olide
There total 4 articles about 2α-bromo-3β-hydroxy-5α-H,4,6β-H-11-phenylselenoeudesman-6,13-olide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / 2percent Pd/SrCO3
2: 68 percent / 0.93M Br2 / CHCl3; CCl4 / 1 h / 0 °C
3: 45 percent / NaBH4 / methanol; H2O / 2 h / Ambient temperature
4: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 2.) -78 deg C, 40 min; -40 deg C, 1.5 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; hydrogen; bromine; lithium diisopropyl amide;
Pd/SrCO3;
In
methanol; tetrachloromethane; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 68 percent / 0.93M Br2 / CHCl3; CCl4 / 1 h / 0 °C
2: 45 percent / NaBH4 / methanol; H2O / 2 h / Ambient temperature
3: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 2.) -78 deg C, 40 min; -40 deg C, 1.5 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; bromine; lithium diisopropyl amide;
In
methanol; tetrachloromethane; chloroform; water;
-
-
62326-48-1
(3S,3aS,5aS,7R,9S,9aR,9bS)-7-bromo-3,5a,9-trimethyloctahydronaphtho[1,2-b]furan-2,8-dione
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 45 percent / NaBH4 / methanol; H2O / 2 h / Ambient temperature
2: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 2.) -78 deg C, 40 min; -40 deg C, 1.5 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium diisopropyl amide;
In
methanol; water;