tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide

Base Information

• Chemical Name: tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide
• CAS No.: 871308-62-2
• Molecular Formula: C₂₂H₂₉N₃O₅S
• Molecular Weight: 447.555
• Mol file: 871308-62-2.mol

Synonyms:

Chemical Property of tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide

There total 3 articles about tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 1-(1H-imidazol-1-ylsulfonyl)piperidin-4-ylcarbamate (871308-56-4) → tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide (871308-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 20 °C

2: 631 mg / acetonitrile / 80 °C

In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2005.08.038

Reference yield:

(piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide (871308-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 9 percent / acetonitrile / 20 °C

2: CH₂Cl₂ / 20 °C

3: 631 mg / acetonitrile / 80 °C

In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2005.08.038

Reference yield:

tert-butyl 1-(1H-imidazol-3-methyl-1-ylsulfonyl)piperidin-4-ylcarbamate trifluoromethanesulfonate + 3-phenoxyaniline (3586-12-7) → tert-butyl piperidin-4-ylcarbamate 4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide (871308-62-2)

Guidance literature:

In acetonitrile; at 80 ℃;

DOI:10.1016/j.bmcl.2005.08.038

upstream raw materials:

3-phenoxyaniline

tert-butyl 1-(1H-imidazol-1-ylsulfonyl)piperidin-4-ylcarbamate

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

4-amino-N-(3-phenoxyphenyl)piperidine-1-sulfonamide

Refernces