2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL

Base Information

• Chemical Name: 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL
• CAS No.: 88014-15-7
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Hs Code.: 2933499090
• Mol file: 88014-15-7.mol

Synonyms:1,2,3,4-Tetrahydro-2-isoquinolineethanol;2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)ethanol; 2-(3,4-Dihydro-1H-isoquinolin-2-yl)ethanol;NSC 59014

Chemical Property of 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL

Chemical Property:

• Vapor Pressure: 0.000282mmHg at 25°C
• Boiling Point: 309.1°C at 760 mmHg
• Flash Point: 156.5°C
• PSA: 23.47000
• Density: 1.091g/cm³
• LogP: 0.97490

Purity/Quality:

98%min ^*data from raw suppliers

2-(3,4-dihydroisoquinolin-2(1H)-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL

There total 15 articles about 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester (88014-09-9) → 2-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanol (88014-15-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Reflux;

DOI:10.1055/s-0039-1690704

Reference yield: 60.0%

→ 2-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanol (88014-15-7)

Guidance literature:

Reference yield: 50.0%

2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline (95071-86-6) → 2-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanol (88014-15-7)

Guidance literature:

2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline; With naphthalene; potassium; In tetrahydrofuran; at -30 ℃; for 5h;

With water; In tetrahydrofuran; at -30 ℃; for 0.5h;

DOI:10.3987/COM-03-9936

upstream raw materials:

oxirane

1,2,3,4-tetrahydroisoquinoline

2-chloro-ethanol

2-(2-hydroxy-ethyl)-isoquinolinium; bromide

Downstream raw materials:

N-(2-methyldiphenylsiloxyethyl)-1,2,3,4-tetrahydroisoquinoline

2-(2-benzyloxy-ethyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolinium; iodide

2-(2-chloro-ethyl)-1,2,3,4-tetrahydro-isoquinoline; hydrochloride

2-[2-(2-methyl-benzyloxy)-ethyl]-1,2,3,4-tetrahydro-isoquinoline

Refernces

• 1、 Segal,Zablotskaya,Lukevics. "Silyl modification of biologically active compounds. 10. Lipid type organosilicon derivatives of 8-hydroxyquinoline and n-(2-hydroxyethyl)-1,2,3,4- tetrahydro(sila, iso)quinolines". . p. 613 - 624. Retrieved 2005.
• 2、 Che, Xin,Gong, Bowen,Liu, Nian,Ning, Shulin,Xiang, Jinbao,Xie, Wenxia,Zhang, Zhuoqi,Zheng, Lianyou. "Diethyl Phosphite Promoted Electrochemical Oxidation of Tetrahydroisoquinolines to 3,4-Dihydroisoquinolin-1(2 H)-ones". supporting information. p. 2077 - 2080. Retrieved 2019/11/05.