2-Propenoic acid,3-cyclohexyl-

Base Information

• Chemical Name: 2-Propenoic acid,3-cyclohexyl-
• CAS No.: 4484-35-9
• Molecular Formula: C9H14 O2
• Molecular Weight: 154.209
• Mol file: 4484-35-9.mol

Synonyms:Cyclohexaneacrylicacid (8CI); 3-Cyclohexylacrylic acid; b-Cyclohexylacrylic acid

Chemical Property of 2-Propenoic acid,3-cyclohexyl-

Chemical Property:

• PSA: 37.30000
• LogP: 2.20750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid,3-cyclohexyl-

There total 18 articles about 2-Propenoic acid,3-cyclohexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

malonic acid (141-82-2) + cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexylacrylic acid (4484-35-9)

Guidance literature:

malonic acid; cyclohexanecarbaldehyde; With piperidine; pyridine; at 20 - 80 ℃; for 6h;

With hydrogenchloride; In water; Cooling with ice;

DOI:10.1016/j.bmc.2011.05.022

Reference yield: 77.0%

cyclohexanepropionic acid (701-97-3) → 3-cyclohexylacrylic acid (4484-35-9)

Guidance literature:

With 6-(quinolin-2-yl)pyridin-2(1H)-one; sodium acetate; palladium diacetate; lithium carbonate; silver carbonate; In 1,4-dioxane; tert-Amyl alcohol; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1126/science.abl3939

Reference yield: 73.0%

carbon dioxide (124-38-9,18923-20-1) + 5,5-dimethyl-2-(2-cyclohexylethen-1-yl)-1,3,2-dioxaborinane (1034330-27-2) → 3-cyclohexylacrylic acid (4484-35-9)

Guidance literature:

carbon dioxide; 5,5-dimethyl-2-(2-cyclohexylethen-1-yl)-1,3,2-dioxaborinane; With copper(l) iodide; cesium fluoride; In N,N-dimethyl-formamide; at 90 ℃; for 10h; under 760.051 Torr;

With hydrogenchloride; water; In N,N-dimethyl-formamide;

DOI:10.1021/ol800829q

upstream raw materials:

piperidine

pyridine

malonic acid

cyclohexanecarbaldehyde

Downstream raw materials:

cyclohexanecarbaldehyde

3-cyclohexylacrylic acid ethyl ester

4-Cyclohexyliden-2-butenal-dimethylhydrazon

3-cyclohexyl-acryloyl chloride

Refernces

• 1、 Wang, Zhen,Hu, Liang,Chekshin, Nikita,Zhuang, Zhe,Qian, Shaoqun,Qiao, Jennifer X.,Yu, Jin-Quan. "Ligand-controlled divergent dehydrogenative reactions of carboxylic acids via C–H activation". . p. 1281 - 1285. Retrieved 2021/12/10.
• 2、 Adamson, Nathan J.,Hull, Ethan,Malcolmson, Steven J.. "Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd-PHOX Catalyst". supporting information. p. 7180 - 7183. Retrieved 2017/06/05.