3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate

Base Information

• Chemical Name: 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate
• CAS No.: 1259394-55-2
• Molecular Formula: C₂₆H₃₈N₂O₅S₂
• Molecular Weight: 522.73
• Mol file: 1259394-55-2.mol

Synonyms:

Chemical Property of 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate

There total 5 articles about 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-[(1S)-amino(4-tolyl)oxido-λ4-sulfanylidene]tosylamide (816444-61-8) + 3,7-dimethyloctyl acetate (5523-95-5,20780-49-8) → 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate (1259394-55-2)

Guidance literature:

With Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene; In methanol; 1,1,2,2-tetrachloroethane; at -35 ℃; for 72h; Inert atmosphere; Molecular sieve;

DOI:10.1039/c0dt00283f

Reference yield:

(1R)-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-1-aminoethylbenzene → 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate (1259394-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 40 h / 35 °C

2: Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene / methanol; 1,1,2,2-tetrachloroethane / 72 h / -35 °C / Inert atmosphere; Molecular sieve

With Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene; trifluoroacetic acid; In methanol; 1,1,2,2-tetrachloroethane;

DOI:10.1039/c0dt00283f

Reference yield:

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl chloride (108875-13-4) → 3,7-dimethyl-7-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-aminoocta-1-yl acetate (1259394-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane; water / 0 - 20 °C

2: trifluoroacetic acid / 40 h / 35 °C

3: Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene / methanol; 1,1,2,2-tetrachloroethane / 72 h / -35 °C / Inert atmosphere; Molecular sieve

With Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene; sodium hydrogencarbonate; trifluoroacetic acid; In methanol; dichloromethane; water; 1,1,2,2-tetrachloroethane;

DOI:10.1039/c0dt00283f

upstream raw materials:

N-[(1S)-amino(4-tolyl)oxido-λ⁴-sulfanylidene]tosylamide

3,7-dimethyloctyl acetate

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl chloride

chloroamine-T

Refernces