2-Bromoquinoxaline

Base Information

• Chemical Name: 2-Bromoquinoxaline
• CAS No.: 36856-91-4
• Molecular Formula: C8H5BrN2
• Molecular Weight: 209.045
• Hs Code.: 29339900
• Mol file: 36856-91-4.mol

Synonyms:2-BROMOQUINOXALINE;2-Bromoquinoxaline ,97%

Chemical Property of 2-Bromoquinoxaline

Chemical Property:

• Vapor Pressure: 0.00844mmHg at 25°C
• Melting Point: 56-60℃
• Refractive Index: 1.685
• Boiling Point: 275.683 °C at 760 mmHg
• PKA: -1.32±0.30(Predicted)
• Flash Point: 120.529 °C
• PSA: 25.78000
• Density: 1.657 g/cm³
• LogP: 2.39230
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromoquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

Useful:

Technology Process of 2-Bromoquinoxaline

There total 17 articles about 2-Bromoquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

quinoxaline-N-oxide (6935-29-1) → 2-bromo-quinoxaline (36856-91-4)

Guidance literature:

With triethylamine; phosphorus(V) oxybromide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2017.02.014

Reference yield: 83.0%

2-hydroxyquinoxaline (1196-57-2,144499-26-3) → 2-bromo-quinoxaline (36856-91-4)

Guidance literature:

With calcium chloride; phosphorus(V) oxybromide; at 155 ℃; for 4h;

DOI:10.1021/jm0503704

Reference yield: 43.0%

quinoxalin-2(1)-one (1196-57-2) → 2-bromo-quinoxaline (36856-91-4)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In 1,4-dioxane; for 4h; Heating;

DOI:10.1002/1522-2675(20010516)84:5<1112::AID-HLCA1112>3.0.CO;2-8

upstream raw materials:

2-hydroxyquinoxaline

quinoxalin-2⁽¹⁾-one

quinoxaline-N-oxide

quinoxaline 1,4-di-N-oxide

Downstream raw materials:

2-ethenylquinoxaline

2-phenethylquinoxaline

1-methyl-3-[[1,1'-biphenyl-5-(carboxymethyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

2-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxaline

Refernces

• 1、 Wang, Dong,Wang, Yuxi,Zhao, Junjie,Li, Linna,Miao, Longfei,Wang, Dong,Sun, Hua,Yu, Peng. "A highly practical and convenient halogenation of fused heterocyclic N-oxides". . p. 5762 - 5768. Retrieved 2016/08/30.
• 2、 Voets, Marieke,Antes, Iris,Scherer, Christiane,Müller-Vieira, Ursula,Biemel, Klaus,Barassin, Catherine,Marchais-Oberwinkler, Sandrine,Hartmann, Rolf W.. "Heteroaryl-substituted naphthalenes and structurally modified derivatives: Selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis". . p. 6632 - 6642. Retrieved 2007/10/03.