C₂₅H₃₃ClF₄N₆O₃

Base Information

• Chemical Name: C₂₅H₃₃ClF₄N₆O₃
• CAS No.: 1510832-43-5
• Molecular Formula: C₂₅H₃₃ClF₄N₆O₃
• Molecular Weight: 577.022
• Mol file: 1510832-43-5.mol

Synonyms:

Chemical Property of C₂₅H₃₃ClF₄N₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₃ClF₄N₆O₃

There total 12 articles about C₂₅H₃₃ClF₄N₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4S)-3-aminopiperidin-4-ol (1510866-72-4) → C25H33ClF4N6O3 (1510832-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 120 °C

2: sodium tris(acetoxy)borohydride / 2-methyltetrahydrofuran

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; butan-1-ol;

Reference yield:

(3RS,4RS)-1-benzyl-3-benzylaminopiperidin-4-ol → C25H33ClF4N6O3 (1510832-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium(II) hydroxide; hydrogen; hydrogenchloride / methanol; ethanol / 48 h / 20 °C / 29995.4 Torr

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 120 °C

3: sodium tris(acetoxy)borohydride / 2-methyltetrahydrofuran

With hydrogenchloride; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; methanol; ethanol; butan-1-ol;

Reference yield:

1-chloro-3-iodo-5-(trifluoromethyl)benzene (1189352-83-7) → C25H33ClF4N6O3 (1510832-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 4 h / 40 °C / Inert atmosphere

2: diisobutylaluminium hydride / 2-methyltetrahydrofuran / -30 °C

3: sodium tris(acetoxy)borohydride / 2-methyltetrahydrofuran

With copper(l) iodide; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; caesium carbonate; N,N`-dimethylethylenediamine; In 2-methyltetrahydrofuran; 1,4-dioxane;

upstream raw materials:

(3S,4S)-3-aminopiperidin-4-ol

1-chloro-3-iodo-5-(trifluoromethyl)benzene

N-benzylpyridinium bromide

(3S,4S)-3-amino-1-(6-amino-5-fluoropyrimidin-4-yl)piperidin-4-ol

Downstream raw materials:

C₂₁H₂₃ClF₄N₆O₂

Refernces