Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester

Base Information

• Chemical Name: Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester
• CAS No.: 1026512-84-4
• Molecular Formula: C₂₃H₃₀NO₅PSi
• Molecular Weight: 459.554
• Mol file: 1026512-84-4.mol

Synonyms:

Chemical Property of Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester

There total 1 articles about Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxiranylmethylisoindole-1,3-dione (5455-98-1) + C12H21O2PSi (848773-38-6) → Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester (1026512-84-4)

Guidance literature:

With zinc(II) chloride; at 20 - 70 ℃; for 24h;

DOI:10.1021/jm00017a016

Reference yield:

Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester (1026512-84-4) → ethyl (3-N-phthalimido-2-hydroxypropyl)benzylphosphinate

Guidance literature:

With acetic acid; In methanol; for 24h; Yield given; Ambient temperature;

DOI:10.1021/jm00017a016

Reference yield:

Benzyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-trimethylsilanyloxy-propyl]-phosphinic acid ethyl ester (1026512-84-4) → (3-amino-2(R,S)-hydroxypropyl)benzylphosphinic acid hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / 24 h / Ambient temperature

2: 80 percent / conc. HCl / 24 h / Heating

With hydrogenchloride; acetic acid; In methanol;

DOI:10.1021/jm00017a016

upstream raw materials:

2-oxiranylmethylisoindole-1,3-dione

C₁₂H₂₁O₂PSi

Refernces