Technology Process of 3,7-dimethyl-10-<3-(5-benzyloxy-4-cyano-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.01,5>undecane
There total 16 articles about 3,7-dimethyl-10-<3-(5-benzyloxy-4-cyano-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.01,5>undecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 860 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature
2: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
3: 92 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
4: hydroxylamine hydrochloride, sodium acetate / methanol; H2O / 0.33 h / 20 - 50 °C
5: 498 percent / acetic anhydride / 1.5 h / Heating
6: OsO4, NaIO4 / tetrahydrofuran; H2O / 2 h
7: NaBH4 / methanol / 0 °C
8: 99 percent / 4-dimethylaminopyridine (DMAP), Et3,N / CH2Cl2 / 1.83 h / Ambient temperature
9: 97 percent / LiBr / acetone / 5 h / Heating
10: 70 percent / NaHCO3 / acetone / 20 h / Heating
With
dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; acetic anhydride; sodium hydride; sodium hydrogencarbonate; triethylamine; pyridinium chlorochromate; lithium bromide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.3891/acta.chem.scand.46-0060
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 1.37 g / 4-dimethylaminopyridine (DMAP), Et3N / CH2Cl2 / 1.5 h
2: 860 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature
3: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
4: 92 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
5: hydroxylamine hydrochloride, sodium acetate / methanol; H2O / 0.33 h / 20 - 50 °C
6: 498 percent / acetic anhydride / 1.5 h / Heating
7: OsO4, NaIO4 / tetrahydrofuran; H2O / 2 h
8: NaBH4 / methanol / 0 °C
9: 99 percent / 4-dimethylaminopyridine (DMAP), Et3,N / CH2Cl2 / 1.83 h / Ambient temperature
10: 97 percent / LiBr / acetone / 5 h / Heating
11: 70 percent / NaHCO3 / acetone / 20 h / Heating
With
dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; acetic anhydride; sodium hydride; sodium hydrogencarbonate; triethylamine; pyridinium chlorochromate; lithium bromide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.3891/acta.chem.scand.46-0060