3H-1,2,3,5-Oxathiadiazole, 4-[(5-chloro-3-benzofuranyl)methyl]-, 2-oxide

Base Information

• Chemical Name: 3H-1,2,3,5-Oxathiadiazole, 4-[(5-chloro-3-benzofuranyl)methyl]-, 2-oxide
• CAS No.: 128105-08-8
• Molecular Formula: C10H7ClN2O3S
• Molecular Weight: 270.696
• Mol file: 128105-08-8.mol

Synonyms:

Chemical Property of 3H-1,2,3,5-Oxathiadiazole, 4-[(5-chloro-3-benzofuranyl)methyl]-, 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3H-1,2,3,5-Oxathiadiazole, 4-[(5-chloro-3-benzofuranyl)methyl]-, 2-oxide

There total 1 articles about 3H-1,2,3,5-Oxathiadiazole, 4-[(5-chloro-3-benzofuranyl)methyl]-, 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chlorobenzofuran-3(2H)-one (3261-05-0) → 4-[(5-chloro-3-benzofuranyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide (128105-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 20 min, 2.) THF, RT, 18 h

2: H₂NOH*HCl, NaOMe / methanol / 18 h / Heating

3: SOCl₂, pyridine / CH₂Cl₂ / 0.33 h

With pyridine; thionyl chloride; hydroxylamine hydrochloride; sodium methylate; sodium hydride; In methanol; dichloromethane;

DOI:10.1021/jm00085a002

upstream raw materials:

5-chlorobenzofuran-3(2H)-one

Refernces